Assay Detail
Binding
CHEMBL654566
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]nitrendipine binding to L-type calcium channel from rat brain cortex homogenate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095177) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.53 | 9.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2093893 | — | — | 1 | 9.69 |
| CHEMBL1314450 | — | — | 1 | 9.30 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 9.08 |
| CHEMBL558616 | — | — | 1 | 8.51 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.33 |
| CHEMBL1598680 | — | — | 1 | 8.15 |
| CHEMBL542169 | — | — | 1 | 7.84 |
| CHEMBL553553 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2093893 | — | Ki | = | 0.205 | nM | 9.69 |
| CHEMBL1314450 | — | Ki | = | 0.499 | nM | 9.30 |
| CHEMBL1484 | NICARDIPINE | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL558616 | — | Ki | = | 3.09 | nM | 8.51 |
| CHEMBL193 | NIFEDIPINE | Ki | = | 4.65 | nM | 8.33 |
| CHEMBL1598680 | — | Ki | = | 7.11 | nM | 8.15 |
| CHEMBL542169 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL553553 | — | Ki | = | 49.6 | nM | 7.30 |