Assay Detail
Binding
CHEMBL654577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit [3H]nitrendipine binding to the calcium channel receptor(CCR) in rat cerebral cortex homogenate; Not active
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095177) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.91 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99871 | — | — | 1 | 5.91 |
| CHEMBL317960 | — | — | 1 | - |
| CHEMBL316826 | — | — | 1 | - |
| CHEMBL416040 | — | — | 1 | - |
| CHEMBL430465 | — | — | 1 | - |
| CHEMBL328405 | — | — | 1 | - |
| CHEMBL321126 | — | — | 1 | - |
| CHEMBL98948 | — | — | 1 | - |
| CHEMBL100175 | — | — | 1 | - |
| CHEMBL284279 | — | — | 1 | - |
| CHEMBL416214 | — | — | 1 | - |
| CHEMBL101655 | — | — | 1 | - |
| CHEMBL317219 | — | — | 1 | - |
| CHEMBL284532 | — | — | 1 | - |
| CHEMBL99182 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99871 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL317960 | — | IC50 | - | nM | - | |
| CHEMBL316826 | — | IC50 | - | nM | - | |
| CHEMBL416040 | — | IC50 | - | nM | - | |
| CHEMBL430465 | — | IC50 | - | nM | - | |
| CHEMBL328405 | — | IC50 | - | nM | - | |
| CHEMBL321126 | — | IC50 | - | nM | - | |
| CHEMBL98948 | — | IC50 | - | nM | - | |
| CHEMBL100175 | — | IC50 | - | nM | - | |
| CHEMBL284279 | — | IC50 | - | nM | - | |
| CHEMBL416214 | — | IC50 | - | nM | - | |
| CHEMBL101655 | — | IC50 | - | nM | - | |
| CHEMBL317219 | — | IC50 | - | nM | - | |
| CHEMBL284532 | — | IC50 | - | nM | - | |
| CHEMBL99182 | — | IC50 | - | nM | - |