Assay Detail
Binding
CHEMBL654652
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Binding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligand
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.50 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105975 | — | — | 1 | 8.70 |
| CHEMBL107128 | — | — | 1 | 8.52 |
| CHEMBL106907 | — | — | 1 | 8.40 |
| CHEMBL104698 | — | — | 1 | 8.30 |
| CHEMBL104793 | — | — | 1 | 8.15 |
| CHEMBL83338 | — | — | 1 | 8.00 |
| CHEMBL317860 | — | — | 1 | 7.89 |
| CHEMBL106381 | — | — | 2 | 7.60 |
| CHEMBL107439 | — | — | 1 | 7.50 |
| CHEMBL79504 | — | — | 1 | 7.46 |
| CHEMBL319233 | — | — | 1 | 7.11 |
| CHEMBL107749 | — | — | 1 | 7.00 |
| CHEMBL319697 | — | — | 1 | 6.70 |
| CHEMBL105109 | — | — | 1 | 6.60 |
| CHEMBL419172 | — | — | 1 | 6.22 |
| CHEMBL314342 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105975 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL107128 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL106907 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL104698 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL104793 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL83338 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL317860 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL106381 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL107439 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL79504 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL319233 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL106381 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL107749 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL319697 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL105109 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL419172 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL314342 | — | IC50 | = | 640.0 | nM | 6.19 |