Assay Detail
Binding
CHEMBL654655
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.99 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157491 | — | — | 1 | 9.89 |
| CHEMBL328260 | — | — | 1 | 9.10 |
| CHEMBL435259 | — | — | 1 | 8.60 |
| CHEMBL423427 | — | — | 1 | 8.30 |
| CHEMBL161093 | — | — | 1 | 8.30 |
| CHEMBL158754 | — | — | 1 | 8.22 |
| CHEMBL159018 | — | — | 1 | 8.10 |
| CHEMBL350763 | — | — | 1 | 7.96 |
| CHEMBL157983 | — | — | 1 | 7.85 |
| CHEMBL159097 | — | — | 1 | 7.57 |
| CHEMBL161594 | — | — | 1 | 7.52 |
| CHEMBL539943 | — | — | 1 | 7.48 |
| CHEMBL350027 | — | — | 1 | 7.37 |
| CHEMBL158438 | — | — | 1 | 7.34 |
| CHEMBL436245 | — | — | 1 | 7.16 |
| CHEMBL161480 | — | — | 1 | 7.07 |
| CHEMBL351973 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157491 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL328260 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL435259 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL423427 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL161093 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL158754 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL159018 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL350763 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL157983 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL159097 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL161594 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL539943 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL350027 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL158438 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL436245 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL161480 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL351973 | — | IC50 | ~ | 27.0 | nM | - |