Assay Detail
Functional
CHEMBL654779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration inhibiting HIV-1 induced cytopathic effects in human T-lymphoblastic cells(CEM-SS) and essentially halted HIV-1 replication.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.69 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93010 | — | — | 1 | 4.89 |
| CHEMBL7121 | (+)-CALANOLIDE B | — | 1 | 4.82 |
| CHEMBL329164 | — | — | 1 | 4.72 |
| CHEMBL267447 | CALANOLIDE A | 1.0 | 1 | 4.70 |
| CHEMBL92528 | — | — | 1 | 4.68 |
| CHEMBL92735 | CALANOLIDE E2 | — | 1 | 4.60 |
| CHEMBL7378 | — | — | 1 | 4.57 |
| CHEMBL263086 | CALANOLIDE C | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93010 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL7121 | (+)-CALANOLIDE B | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL329164 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL267447 | CALANOLIDE A | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL92528 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL92735 | CALANOLIDE E2 | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL7378 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL263086 | CALANOLIDE C | IC50 | = | 30000.0 | nM | 4.52 |