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Assay Detail

CHEMBL654787

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration is tested in HIV-1 Lai-infected CEM-SS cells
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CEM-SS
Confidence 1 — Organism
Curated By Intermediate

Target

CEM-SS (CHEMBL614548)
Type CELL-LINE
Organism Homo sapiens

Publication

Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Moreau P, Anizon F, Sancelme M, Prudhomme M, Bailly C, Carrasco C, Ollier M, Sevère D, Riou JF, Fabbro D, Meyer T, Aubertin AM.
J Med Chem (1998) 41 : 1631 -1640
PubMed 9572888 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.87 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3350557 1 6.80
CHEMBL3350563 1 6.51
CHEMBL3350556 1 6.44
CHEMBL370100 REBECCAMYCIN 1 6.28
CHEMBL3350561 1 6.22
CHEMBL3350555 1 5.39
CHEMBL3350560 1 5.38
CHEMBL3350564 1 5.31
CHEMBL3350558 2 5.30
CHEMBL3350559 1 -
CHEMBL3350565 1 -
CHEMBL3350566 1 -
CHEMBL3350562 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3350557 IC50 = 160.0 nM 6.80
CHEMBL3350563 IC50 = 310.0 nM 6.51
CHEMBL3350556 IC50 = 360.0 nM 6.44
CHEMBL370100 REBECCAMYCIN IC50 = 520.0 nM 6.28
CHEMBL3350561 IC50 = 600.0 nM 6.22
CHEMBL3350555 IC50 = 4100.0 nM 5.39
CHEMBL3350560 IC50 = 4170.0 nM 5.38
CHEMBL3350564 IC50 = 4850.0 nM 5.31
CHEMBL3350558 IC50 = 5060.0 nM 5.30
CHEMBL3350558 IC50 = 8700.0 nM 5.06
CHEMBL3350559 IC50 > 19000.0 nM -
CHEMBL3350565 IC50 > 1980.0 nM -
CHEMBL3350566 IC50 > 9400.0 nM -
CHEMBL3350562 IC50 > 9700.0 nM -