Assay Detail
Binding
CHEMBL654808
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In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.95 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20896 | — | — | 1 | 10.00 |
| CHEMBL320386 | — | — | 1 | 10.00 |
| CHEMBL102826 | — | — | 1 | 10.00 |
| CHEMBL316475 | — | — | 1 | 10.00 |
| CHEMBL99909 | — | — | 1 | 9.70 |
| CHEMBL319593 | — | — | 1 | 9.70 |
| CHEMBL322603 | — | — | 2 | 9.30 |
| CHEMBL318406 | — | — | 1 | 9.15 |
| CHEMBL101961 | — | — | 1 | 9.10 |
| CHEMBL103343 | — | — | 1 | 9.00 |
| CHEMBL99788 | — | — | 1 | 9.00 |
| CHEMBL103813 | — | — | 1 | 9.00 |
| CHEMBL318210 | — | — | 1 | 8.70 |
| CHEMBL102675 | — | — | 1 | 8.52 |
| CHEMBL318681 | — | — | 1 | 8.52 |
| CHEMBL101333 | — | — | 1 | 8.44 |
| CHEMBL103782 | — | — | 1 | 8.40 |
| CHEMBL100958 | — | — | 1 | 8.40 |
| CHEMBL100596 | — | — | 1 | 8.30 |
| CHEMBL102674 | — | — | 1 | 8.22 |
| CHEMBL322232 | — | — | 1 | 7.62 |
| CHEMBL322693 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320386 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL102826 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL20896 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL316475 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL319593 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL99909 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL322603 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL322603 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL318406 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL101961 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL103343 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL103813 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL99788 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL318210 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL102675 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL318681 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL101333 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL103782 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL100958 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL100596 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL102674 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL322232 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL322693 | — | IC50 | = | 36.0 | nM | 7.44 |