Assay Detail
Functional
CHEMBL654819
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Antiviral activity against HIV-1 (RF strain) in C8166 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.86 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.07 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 6.90 |
| CHEMBL2448180 | — | — | 1 | 6.16 |
| CHEMBL366193 | — | — | 1 | 5.00 |
| CHEMBL69441 | — | — | 1 | 5.00 |
| CHEMBL1256387 | — | — | 1 | 4.00 |
| CHEMBL68878 | — | — | 1 | - |
| CHEMBL421299 | — | — | 1 | - |
| CHEMBL68883 | — | — | 1 | - |
| CHEMBL543345 | — | — | 1 | - |
| CHEMBL68775 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL853 | ZALCITABINE | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL2448180 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL366193 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL69441 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1256387 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL68878 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL421299 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL68883 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL543345 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL68775 | — | IC50 | > | 100000.0 | nM | - |