Assay Detail
Binding
CHEMBL654867
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Butyrylcholinesterase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.79 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 8.09 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.14 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL95 | TACRINE | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 7138.0 | nM | 5.15 |