Assay Detail
Binding
CHEMBL654869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against Butyrylcholinesterase obtained from rat plasma
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.50 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.14 |
| CHEMBL542744 | — | — | 1 | 5.00 |
| CHEMBL138107 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL542744 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL138107 | — | IC50 | = | 42325.0 | nM | 4.37 |