Assay Detail
Binding
CHEMBL654870
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Inhibition of rat serum butyrylcholinesterase, in the presence of a specific AChE inhibitor; BW284c51
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.60 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 7.04 |
| CHEMBL557225 | — | — | 1 | 6.98 |
| CHEMBL545539 | — | — | 1 | 6.96 |
| CHEMBL542236 | — | — | 1 | 6.90 |
| CHEMBL542732 | — | — | 1 | 6.84 |
| CHEMBL555320 | — | — | 1 | 6.83 |
| CHEMBL544369 | — | — | 1 | 6.81 |
| CHEMBL543906 | — | — | 1 | 6.80 |
| CHEMBL541853 | — | — | 1 | 6.77 |
| CHEMBL543667 | — | — | 1 | 6.70 |
| CHEMBL544605 | — | — | 1 | 6.70 |
| CHEMBL542477 | — | — | 1 | 6.62 |
| CHEMBL542234 | — | — | 1 | 6.52 |
| CHEMBL540830 | — | — | 1 | 6.45 |
| CHEMBL542482 | — | — | 1 | 6.42 |
| CHEMBL544143 | — | — | 1 | 6.37 |
| CHEMBL539811 | — | — | 1 | 6.24 |
| CHEMBL540837 | — | — | 1 | 6.17 |
| CHEMBL545774 | — | — | 1 | 6.16 |
| CHEMBL538533 | — | — | 1 | 6.16 |
| CHEMBL544603 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL557225 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL545539 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL542236 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL542732 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL555320 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL544369 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL543906 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL541853 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL543667 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL544605 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL542477 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL542234 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL540830 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL542482 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL544143 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL539811 | — | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL540837 | — | IC50 | = | 682.0 | nM | 6.17 |
| CHEMBL545774 | — | IC50 | = | 687.0 | nM | 6.16 |
| CHEMBL538533 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL544603 | — | IC50 | = | 791.0 | nM | 6.10 |