Assay Detail
Binding
CHEMBL654873
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Inhibitory potency against rat serum Butyrylcholinesterase with BW284c51 as AChE inhibitor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.75 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76658 | — | — | 1 | 7.09 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.04 |
| CHEMBL32823 | — | — | 1 | 6.83 |
| CHEMBL74607 | — | — | 1 | 6.82 |
| CHEMBL77374 | — | — | 1 | 6.78 |
| CHEMBL1202837 | — | — | 1 | 6.66 |
| CHEMBL1202834 | — | — | 1 | 6.65 |
| CHEMBL1202835 | — | — | 1 | 6.64 |
| CHEMBL1202836 | — | — | 1 | 6.63 |
| CHEMBL76659 | — | — | 1 | 6.36 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76658 | — | IC50 | = | 81.5 | nM | 7.09 |
| CHEMBL95 | TACRINE | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL32823 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL74607 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL77374 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL1202837 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1202834 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL1202835 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL1202836 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL76659 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 135000.0 | nM | - |