Assay Detail
Binding
CHEMBL654875
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Inhibition of isolated Butyrylcholinesterase (BuChE )
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.43 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340625 | — | — | 1 | 8.44 |
| CHEMBL128202 | — | — | 1 | 7.68 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.64 |
| CHEMBL130918 | — | — | 1 | 7.62 |
| CHEMBL128863 | — | — | 1 | 7.58 |
| CHEMBL128471 | — | — | 1 | 7.33 |
| CHEMBL340427 | XANTHOSTIGMINE | — | 1 | 7.32 |
| CHEMBL440526 | — | — | 1 | 7.19 |
| CHEMBL131827 | — | — | 1 | 7.12 |
| CHEMBL337999 | — | — | 1 | 7.08 |
| CHEMBL128260 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340625 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL128202 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL130918 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL128863 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL128471 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL340427 | XANTHOSTIGMINE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL440526 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL131827 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL337999 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL128260 | — | IC50 | = | 200.0 | nM | 6.70 |