Assay Detail
Binding
CHEMBL654884
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Ability to inhibit butyrylcholinesterase (BChE), freshly prepared from human plasma
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.75 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54470 | — | — | 1 | 9.00 |
| CHEMBL54577 | — | — | 1 | 8.22 |
| CHEMBL54420 | — | — | 1 | 8.08 |
| CHEMBL417915 | — | — | 1 | 7.30 |
| CHEMBL294208 | — | — | 1 | 7.11 |
| CHEMBL293720 | — | — | 1 | 7.07 |
| CHEMBL300808 | — | — | 1 | 6.88 |
| CHEMBL54864 | — | — | 1 | 6.40 |
| CHEMBL54014 | — | — | 1 | 6.22 |
| CHEMBL292695 | — | — | 1 | 6.19 |
| CHEMBL55315 | — | — | 1 | 5.84 |
| CHEMBL54727 | — | — | 1 | 5.81 |
| CHEMBL54956 | — | — | 1 | 5.75 |
| CHEMBL300143 | — | — | 1 | 5.71 |
| CHEMBL53623 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54470 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL54577 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL54420 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL417915 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL294208 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL293720 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL300808 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL54864 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL54014 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL292695 | — | IC50 | = | 641.0 | nM | 6.19 |
| CHEMBL55315 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL54727 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL54956 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL300143 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL53623 | — | IC50 | = | 2165.0 | nM | 5.67 |