Assay Detail
Functional
CHEMBL654903
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Compound was tested for antiviral activity against the CEM-SS cell lines infected with HIV-1.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.91 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146894 | — | — | 1 | 7.52 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | 4.0 | 1 | 7.40 |
| CHEMBL343403 | — | — | 1 | 7.30 |
| CHEMBL146139 | — | — | 1 | 7.05 |
| CHEMBL146647 | — | — | 1 | 7.00 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 6.38 |
| CHEMBL148179 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146894 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL343403 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL146139 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL146647 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL148179 | — | EC50 | = | 2000.0 | nM | 5.70 |