Assay Detail
Functional
CHEMBL654909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound is screened for cell growth inhibition against CCRF-CEM cell line, a human lymphoblastic leukemia line of T-cell origin
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of novel 2,6-diaminobenz[cd]indole inhibitors of thymidylate synthase using the protein structure as a guide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.70 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56523 | — | — | 1 | 6.36 |
| CHEMBL55263 | — | — | 1 | 6.35 |
| CHEMBL9440 | METESIND | 2.0 | 1 | 6.34 |
| CHEMBL57420 | — | — | 1 | 6.11 |
| CHEMBL59203 | — | — | 1 | 5.96 |
| CHEMBL56637 | — | — | 1 | 5.70 |
| CHEMBL434980 | — | — | 1 | 5.64 |
| CHEMBL55884 | — | — | 1 | 5.62 |
| CHEMBL56611 | — | — | 1 | 5.52 |
| CHEMBL294871 | — | — | 1 | 5.52 |
| CHEMBL293810 | — | — | 1 | 5.43 |
| CHEMBL293823 | — | — | 1 | 5.40 |
| CHEMBL55361 | — | — | 1 | 5.29 |
| CHEMBL301218 | — | — | 1 | 5.23 |
| CHEMBL417763 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56523 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL55263 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL9440 | METESIND | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL57420 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL59203 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL56637 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL434980 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL55884 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL56611 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL294871 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL293810 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL293823 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL55361 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL301218 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL417763 | — | IC50 | = | 9000.0 | nM | 5.05 |