Assay Detail
Binding
CHEMBL654915
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Inhibitory activity against beta-Lactamase enzyme derived from Escherichia coli WC3310 TEM-2
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.14 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35987 | — | — | 1 | 8.52 |
| CHEMBL268919 | — | — | 1 | 8.30 |
| CHEMBL36657 | — | — | 1 | 7.43 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 7.22 |
| CHEMBL287095 | — | — | 1 | 6.92 |
| CHEMBL284539 | — | — | 1 | 6.87 |
| CHEMBL290112 | — | — | 1 | 6.51 |
| CHEMBL290165 | — | — | 1 | 6.40 |
| CHEMBL37794 | — | — | 1 | 6.10 |
| CHEMBL39640 | — | — | 1 | - |
| CHEMBL36888 | — | — | 1 | - |
| CHEMBL34981 | — | — | 1 | - |
| CHEMBL269308 | — | — | 1 | - |
| CHEMBL36689 | — | — | 1 | - |
| CHEMBL36213 | — | — | 1 | - |
| CHEMBL33895 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35987 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL268919 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL36657 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL287095 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL284539 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL290112 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL290165 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL37794 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL39640 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL36888 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL34981 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL269308 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL36689 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL36213 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL33895 | — | IC50 | > | 20000.0 | nM | - |