Assay Detail
Functional
CHEMBL654960
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Beta-adrenergic agonistic activity in rat proximal colon in presence of phentolamine (10 uM), desmethylimipramine (0.5 uM) and hydrocortisone (30 uM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Colon |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of the potent and selective atypical -adrenergic agonist SR 59062A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.82 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543099 | — | — | 1 | 9.05 |
| CHEMBL553039 | — | — | 1 | 8.96 |
| CHEMBL545437 | AMIBEGRON HYDROCHLORIDE | 3.0 | 1 | 8.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543099 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL553039 | — | IC50 | = | 1.09 | nM | 8.96 |
| CHEMBL545437 | AMIBEGRON HYDROCHLORIDE | IC50 | = | 3.5 | nM | 8.46 |