Assay Detail
Functional
CHEMBL654961
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Beta-adrenergic agonistic activity in rat uterus preincubated with phenoxybenzamine (12 uM) for 30 min
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Uterus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of the potent and selective atypical -adrenergic agonist SR 59062A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.37 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541542 | — | — | 1 | 6.73 |
| CHEMBL553039 | — | — | 1 | 6.50 |
| CHEMBL543333 | — | — | 1 | 6.46 |
| CHEMBL543099 | — | — | 1 | 6.32 |
| CHEMBL545437 | AMIBEGRON HYDROCHLORIDE | 3.0 | 2 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541542 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL553039 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL543333 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL543099 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL545437 | AMIBEGRON HYDROCHLORIDE | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL545437 | AMIBEGRON HYDROCHLORIDE | IC50 | = | 1200.0 | nM | 5.92 |