Assay Detail
Functional
CHEMBL654971
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Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.70 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267447 | CALANOLIDE A | 1.0 | 2 | 6.57 |
| CHEMBL269090 | — | — | 1 | 5.92 |
| CHEMBL267693 | — | — | 1 | 5.77 |
| CHEMBL7840 | — | — | 1 | 5.70 |
| CHEMBL7211 | — | — | 1 | 5.64 |
| CHEMBL267679 | — | — | 1 | 5.62 |
| CHEMBL7378 | — | — | 1 | 5.55 |
| CHEMBL266552 | — | — | 1 | 5.24 |
| CHEMBL7242 | — | — | 1 | 5.21 |
| CHEMBL266091 | — | — | 1 | 5.14 |
| CHEMBL269063 | — | — | 1 | - |
| CHEMBL266050 | — | — | 1 | - |
| CHEMBL7633 | — | — | 1 | - |
| CHEMBL7270 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL269090 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL267693 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL7840 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL7211 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL267679 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL7378 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL266552 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL7242 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL266091 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL269063 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL266050 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL7633 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL7270 | — | EC50 | > | 100000.0 | nM | - |