Assay Detail
Functional
CHEMBL655049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against HIV-1 strain 111B in acutely infected C8166 T cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.81 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304086 | — | — | 1 | 8.43 |
| CHEMBL13134 | PALINAVIR | 2.0 | 1 | 8.30 |
| CHEMBL66460 | — | — | 1 | 8.24 |
| CHEMBL1790509 | — | — | 1 | 8.15 |
| CHEMBL69062 | — | — | 1 | 8.03 |
| CHEMBL66399 | — | — | 1 | 7.96 |
| CHEMBL1790508 | — | — | 1 | 7.89 |
| CHEMBL68721 | — | — | 1 | 7.82 |
| CHEMBL71334 | — | — | 1 | 7.46 |
| CHEMBL69755 | — | — | 1 | 6.90 |
| CHEMBL1790510 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304086 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL13134 | PALINAVIR | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL66460 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1790509 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL69062 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL66399 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1790508 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL68721 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL71334 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL69755 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL1790510 | — | EC50 | = | 165.0 | nM | 6.78 |