Assay Detail
Functional
CHEMBL655070
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Changes in potassium fluxes assessed in the glucose responsive insulin-producing murine cell line beta-TC3
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Murine cell line |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 5.95 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134168 | — | — | 1 | 7.85 |
| CHEMBL336621 | — | — | 1 | 7.10 |
| CHEMBL341410 | — | — | 1 | 7.00 |
| CHEMBL442023 | — | — | 1 | 6.70 |
| CHEMBL135091 | — | — | 1 | 6.70 |
| CHEMBL3350271 | — | — | 1 | 6.52 |
| CHEMBL2111887 | — | — | 1 | 6.52 |
| CHEMBL336586 | — | — | 1 | 6.40 |
| CHEMBL134255 | — | — | 1 | 6.40 |
| CHEMBL132075 | — | — | 1 | 6.40 |
| CHEMBL134253 | — | — | 1 | 6.30 |
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | 6.22 |
| CHEMBL131971 | — | — | 1 | 6.22 |
| CHEMBL335640 | — | — | 1 | 6.22 |
| CHEMBL3350270 | — | — | 1 | 6.10 |
| CHEMBL135145 | — | — | 1 | 6.00 |
| CHEMBL134220 | — | — | 1 | 5.89 |
| CHEMBL133663 | — | — | 1 | 5.85 |
| CHEMBL133596 | — | — | 1 | 5.70 |
| CHEMBL134254 | — | — | 1 | 5.70 |
| CHEMBL337442 | — | — | 1 | 5.10 |
| CHEMBL335477 | — | — | 1 | 5.05 |
| CHEMBL2111888 | — | — | 1 | 4.85 |
| CHEMBL134039 | — | — | 1 | 4.77 |
| CHEMBL135240 | — | — | 1 | 4.70 |
| CHEMBL134120 | — | — | 1 | 4.39 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.11 |
| CHEMBL133699 | — | — | 1 | - |
| CHEMBL334826 | — | — | 1 | - |
| CHEMBL341435 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134168 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL336621 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL341410 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL442023 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL135091 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3350271 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2111887 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL336586 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL134255 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL132075 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL134253 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL135191 | TIFENAZOXIDE | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL131971 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL335640 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3350270 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL135145 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL134220 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL133663 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL133596 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL134254 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL337442 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL335477 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2111888 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL134039 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL135240 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL134120 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 77400.0 | nM | 4.11 |
| CHEMBL133699 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL334826 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL341435 | — | EC50 | > | 100000.0 | nM | - |