Compound Detail
CHEMBL133663
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Basic Information
| ChEMBL ID | CHEMBL133663 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZHGCRRVSTOTYSM-UHFFFAOYSA-N |
4
Targets
8
Activities
2
Assay Types
3
PK Parameters
5
Publications
0
Known Names
Molecular Properties
291.8
MW (Da)
1.82
ALogP
5
HBA
2
HBD
70.6
PSA (Ų)
0.83
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.3
EC50 3 meas. best 5.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
| Sulfonylurea receptor 1, Kir6.2 CHEMBL2096972 | IC50 | 6.92 | 6.92 | 120.0 | 1 |
| Beta-TC6 CHEMBL614357 | IC50 | 6.31 | 6.31 | 490.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Rattus norvegicus CHEMBL376 | EC50 | 4.57 | 4.49 | 27000.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | -1237.0 | % | - |
| F | 49.0 | % | Rattus norvegicus |
| T1/2 | 1.883 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | IC50 | = | 50.0 | nM | 7.3 | Inhibition of glucose-stimulated insulin release from Wistar rat islets | 12213059 |
| Sulfonylurea receptor 1, Kir6.2 | IC50 | = | 120.0 | nM | 6.92 | Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulf... | 12213059 |
| Beta-TC6 | IC50 | = | 490.0 | nM | 6.31 | Ability to inhibit the release of insulin from the mouse beta-TC6 cell line | 12213059 |
| Unchecked | EC50 | = | 1400.0 | nM | 5.85 | Changes in potassium fluxes assessed in the glucose responsive insulin-producing... | 12213059 |
| Rattus norvegicus | EC50 | = | 27000.0 | nM | 4.57 | Ability to relax phenylephrine-contracted rat aorta rings | 12213059 |
| Rattus norvegicus | EC50 | = | 38600.0 | nM | 4.41 | Vasodilation effects on Wistar rat mesenteric arteries precontracted with phenyl... | 12213059 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12213059 | 10.1021/jm0208121 | Rattus norvegicus | 7 |
| 12213059 | 10.1021/jm0208121 | Sulfonylurea receptor 1, Kir6.2 | 3 |
| 12213059 | 10.1021/jm0208121 | Beta-TC6 | 2 |
| 12213059 | 10.1021/jm0208121 | ADMET | 2 |
| 12213059 | 10.1021/jm0208121 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine