Assay Detail
Functional
CHEMBL779272
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Vasodilation effects on Wistar rat mesenteric arteries precontracted with phenylephrine
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 4.72 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131971 | — | — | 1 | 5.21 |
| CHEMBL134168 | — | — | 1 | 5.14 |
| CHEMBL132075 | — | — | 1 | 4.97 |
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | 4.84 |
| CHEMBL3350270 | — | — | 1 | 4.72 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.68 |
| CHEMBL133596 | — | — | 1 | 4.63 |
| CHEMBL2111887 | — | — | 1 | 4.60 |
| CHEMBL135091 | — | — | 1 | 4.53 |
| CHEMBL133663 | — | — | 1 | 4.41 |
| CHEMBL336586 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131971 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL134168 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL132075 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL135191 | TIFENAZOXIDE | EC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL3350270 | — | EC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL133596 | — | EC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL2111887 | — | EC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL135091 | — | EC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL133663 | — | EC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL336586 | — | EC50 | = | 60600.0 | nM | 4.22 |