Assay Detail
Functional
CHEMBL780694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to relax phenylephrine-contracted rat aorta rings
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 4.90 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442023 | — | — | 1 | 6.82 |
| CHEMBL135145 | — | — | 1 | 5.85 |
| CHEMBL134039 | — | — | 1 | 5.70 |
| CHEMBL134255 | — | — | 1 | 5.70 |
| CHEMBL341410 | — | — | 1 | 5.48 |
| CHEMBL336621 | — | — | 1 | 5.21 |
| CHEMBL134168 | — | — | 1 | 5.19 |
| CHEMBL337442 | — | — | 1 | 5.17 |
| CHEMBL334826 | — | — | 1 | 5.10 |
| CHEMBL135091 | — | — | 1 | 4.93 |
| CHEMBL335640 | — | — | 1 | 4.87 |
| CHEMBL341435 | — | — | 1 | 4.76 |
| CHEMBL135240 | — | — | 1 | 4.69 |
| CHEMBL134254 | — | — | 1 | 4.60 |
| CHEMBL133663 | — | — | 1 | 4.57 |
| CHEMBL133699 | — | — | 1 | 4.55 |
| CHEMBL136005 | — | — | 1 | 4.46 |
| CHEMBL3350270 | — | — | 1 | 4.29 |
| CHEMBL133596 | — | — | 1 | 4.19 |
| CHEMBL134220 | — | — | 1 | 4.19 |
| CHEMBL2111887 | — | — | 1 | 4.16 |
| CHEMBL3350271 | — | — | 1 | 4.12 |
| CHEMBL134120 | — | — | 1 | 4.08 |
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | - |
| CHEMBL2111888 | — | — | 1 | - |
| CHEMBL131971 | — | — | 1 | - |
| CHEMBL134253 | — | — | 1 | - |
| CHEMBL132075 | — | — | 1 | - |
| CHEMBL336586 | — | — | 1 | - |
| CHEMBL335477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442023 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL135145 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL134039 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL134255 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL341410 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL336621 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL134168 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL337442 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL334826 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL135091 | — | EC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL335640 | — | EC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL341435 | — | EC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL135240 | — | EC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL134254 | — | EC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL133663 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL133699 | — | EC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL136005 | — | EC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL3350270 | — | EC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL133596 | — | EC50 | = | 64700.0 | nM | 4.19 |
| CHEMBL134220 | — | EC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL2111887 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL3350271 | — | EC50 | = | 75300.0 | nM | 4.12 |
| CHEMBL134120 | — | EC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL135191 | TIFENAZOXIDE | EC50 | = | 119200.0 | nM | - |
| CHEMBL2111888 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL131971 | — | EC50 | = | 266000.0 | nM | - |
| CHEMBL134253 | — | EC50 | = | 176200.0 | nM | - |
| CHEMBL132075 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL336586 | — | EC50 | = | 169000.0 | nM | - |
| CHEMBL335477 | — | EC50 | = | 135500.0 | nM | - |
| CHEMBL445330 | — | EC50 | = | 262000.0 | nM | - |