Assay Detail
Functional
CHEMBL655108
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Tested for cell growth inhibition in CCRF-CEM lymphoblasts
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.01 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104770 | — | — | 1 | 5.43 |
| CHEMBL108006 | — | — | 1 | 4.92 |
| CHEMBL104555 | — | — | 1 | 4.85 |
| CHEMBL320811 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104770 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL108006 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL104555 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL320811 | — | IC50 | = | 15000.0 | nM | 4.82 |