Assay Detail
Functional
CHEMBL655109
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Tested in vitro for cellular cytotoxicity against human T-cell derived lymphoblastic leukemia (CCRF-CEM) cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of a pyrimido[4,5-b]azepine analog of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.65 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34412 | LOMETREXOL | 2.0 | 1 | 7.82 |
| CHEMBL170101 | — | — | 1 | 7.80 |
| CHEMBL3085263 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34412 | LOMETREXOL | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL170101 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3085263 | — | IC50 | = | 47.0 | nM | 7.33 |