Assay Detail
Functional
CHEMBL655110
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The concentration required to inhibit cell growth to 50% of untreated controls in human T-cell leukemia CCRF-CEM cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.68 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445596 | 4'-THIOTHYMIDINE | — | 1 | 6.17 |
| CHEMBL1169491 | — | — | 1 | 5.46 |
| CHEMBL1790571 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445596 | 4'-THIOTHYMIDINE | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1169491 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1790571 | — | IC50 | = | 4000.0 | nM | 5.40 |