Assay Detail
Functional
CHEMBL655148
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Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.22 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 8.70 |
| CHEMBL114283 | DANIQUIDONE | 2.0 | 1 | 4.85 |
| CHEMBL326173 | — | — | 1 | 4.22 |
| CHEMBL114408 | — | — | 1 | 4.17 |
| CHEMBL279460 | — | — | 1 | 4.15 |
| CHEMBL113955 | — | — | 1 | - |
| CHEMBL325293 | — | — | 1 | - |
| CHEMBL116472 | — | — | 1 | - |
| CHEMBL113903 | — | — | 1 | - |
| CHEMBL114069 | — | — | 1 | - |
| CHEMBL117759 | — | — | 1 | - |
| CHEMBL113904 | — | — | 1 | - |
| CHEMBL113819 | — | — | 1 | - |
| CHEMBL116753 | — | — | 1 | - |
| CHEMBL114002 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL114283 | DANIQUIDONE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL326173 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL114408 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL279460 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL113955 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL325293 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL116472 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL113903 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL114069 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL117759 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL113904 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL113819 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL116753 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL114002 | — | IC50 | > | 200000.0 | nM | - |