Assay Detail
Functional
CHEMBL655272
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50% inhibitory concentration for cytopathicity of HIV-1 RF in CEM-SS cells.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel modifications in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.94 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107200 | — | — | 1 | 8.89 |
| CHEMBL294840 | — | — | 1 | 7.89 |
| CHEMBL144701 | — | — | 1 | 5.82 |
| CHEMBL134059 | — | — | 1 | 5.72 |
| CHEMBL144654 | — | — | 1 | 5.55 |
| CHEMBL141323 | — | — | 1 | 5.55 |
| CHEMBL142532 | — | — | 1 | 5.32 |
| CHEMBL144209 | — | — | 1 | 5.19 |
| CHEMBL357187 | — | — | 1 | 5.15 |
| CHEMBL144121 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107200 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL294840 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL144701 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL134059 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL144654 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL141323 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL142532 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL144209 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL357187 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL144121 | — | EC50 | = | 50500.0 | nM | 4.30 |