Assay Detail

CHEMBL655283

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Anti-HIV activity was measured against HIV-1 Promonocytropic TPI clinical isolates in CEM-SS cells

ChEMBL ↗

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Target

CEM-SS (CHEMBL614548) ↗

Open DB target context

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Primary target CEM-SS

CHEMBL614548

Anchored from Assay target.

Protein identity CEM-SS

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CEM-SS
Confidence	1 — Organism
Curated By	Intermediate

Target

CEM-SS (CHEMBL614548) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Anti-HIV michellamines from Ancistrocladus korupensis.

Boyd MR, Hallock YF, Cardellina JH, Manfredi KP, Blunt JW, McMahon JB, Buckheit RW, Bringmann G, Schäffer M, Cragg GM.
J Med Chem (1994) 37 : 1740 -1745
PubMed 8021914 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	5.22	5.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL295292	MICHELLAMINE A	—	1	5.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL295292	MICHELLAMINE A	EC50	=	6000.0	nM	5.22