Assay Detail
Functional
CHEMBL655292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV-1 activity in CEM-SS cells was measured by the quantification of the reverse transcriptase activity, associated with the virus particles released from HIV-1 infected cells in the culture medium.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.42 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347684 | — | — | 1 | 6.92 |
| CHEMBL347195 | — | — | 1 | 6.82 |
| CHEMBL3350557 | — | — | 1 | 6.80 |
| CHEMBL156776 | — | — | 1 | 6.48 |
| CHEMBL345384 | — | — | 1 | 6.35 |
| CHEMBL154620 | — | — | 1 | 6.30 |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 6.28 |
| CHEMBL345881 | — | — | 1 | 6.01 |
| CHEMBL347466 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347684 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL347195 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3350557 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL156776 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL345384 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL154620 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL345881 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL347466 | — | IC50 | = | 1400.0 | nM | 5.85 |