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Assay Detail

CHEMBL655294

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV-1 infected CEM-SS cells was determined in XTT cytoprotection assay
78
Total Activities
78
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type CEM-SS
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers.
Turpin JA, Song Y, Inman JK, Huang M, Wallqvist A, Maynard A, Covell DG, Rice WG, Appella E.
J Med Chem (1999) 42 : 67 -86
PubMed 9888834 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 78 4.43 4.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL279627 1 4.90
CHEMBL422908 1 4.79
CHEMBL355016 1 4.77
CHEMBL168487 1 4.76
CHEMBL353645 1 4.75
CHEMBL169224 1 4.75
CHEMBL168321 1 4.75
CHEMBL353817 1 4.74
CHEMBL352423 1 4.74
CHEMBL354032 1 4.74
CHEMBL424547 1 4.73
CHEMBL169499 1 4.72
CHEMBL169630 1 4.71
CHEMBL353646 1 4.71
CHEMBL353730 1 4.66
CHEMBL354052 1 4.65
CHEMBL168225 1 4.56
CHEMBL168527 1 4.49
CHEMBL168937 1 4.47
CHEMBL168853 1 4.41
CHEMBL352413 1 4.40
CHEMBL354943 1 4.37
CHEMBL353437 1 4.36
CHEMBL171114 1 4.36
CHEMBL172615 1 4.34
CHEMBL368730 1 4.34
CHEMBL355890 1 4.33
CHEMBL355181 1 4.33
CHEMBL355324 1 4.33
CHEMBL169480 1 4.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL279627 IC50 = 12700.0 nM 4.90
CHEMBL422908 IC50 = 16200.0 nM 4.79
CHEMBL355016 IC50 = 17100.0 nM 4.77
CHEMBL168487 IC50 = 17300.0 nM 4.76
CHEMBL353645 IC50 = 17800.0 nM 4.75
CHEMBL169224 IC50 = 18000.0 nM 4.75
CHEMBL168321 IC50 = 17600.0 nM 4.75
CHEMBL353817 IC50 = 18300.0 nM 4.74
CHEMBL352423 IC50 = 18100.0 nM 4.74
CHEMBL354032 IC50 = 18200.0 nM 4.74
CHEMBL424547 IC50 = 18600.0 nM 4.73
CHEMBL169499 IC50 = 19200.0 nM 4.72
CHEMBL353646 IC50 = 19500.0 nM 4.71
CHEMBL169630 IC50 = 19400.0 nM 4.71
CHEMBL353730 IC50 = 21700.0 nM 4.66
CHEMBL354052 IC50 = 22200.0 nM 4.65
CHEMBL168225 IC50 = 27600.0 nM 4.56
CHEMBL168527 IC50 = 32200.0 nM 4.49
CHEMBL168937 IC50 = 34000.0 nM 4.47
CHEMBL168853 IC50 = 39000.0 nM 4.41
CHEMBL352413 IC50 = 39700.0 nM 4.40
CHEMBL354943 IC50 = 43000.0 nM 4.37
CHEMBL353437 IC50 = 44200.0 nM 4.36
CHEMBL171114 IC50 = 43700.0 nM 4.36
CHEMBL368730 IC50 = 45700.0 nM 4.34
CHEMBL172615 IC50 = 45500.0 nM 4.34
CHEMBL355890 IC50 = 46400.0 nM 4.33
CHEMBL355181 IC50 = 46400.0 nM 4.33
CHEMBL355324 IC50 = 46500.0 nM 4.33
CHEMBL169480 IC50 = 49500.0 nM 4.30
CHEMBL354765 IC50 = 50800.0 nM 4.29
CHEMBL353498 IC50 = 52800.0 nM 4.28
CHEMBL169773 IC50 = 52500.0 nM 4.28
CHEMBL352691 IC50 = 54100.0 nM 4.27
CHEMBL354684 IC50 = 53800.0 nM 4.27
CHEMBL168996 IC50 = 53700.0 nM 4.27
CHEMBL440929 IC50 = 54600.0 nM 4.26
CHEMBL433537 IC50 = 55500.0 nM 4.26
CHEMBL169678 IC50 = 55000.0 nM 4.26
CHEMBL169942 IC50 = 54700.0 nM 4.26
CHEMBL443037 IC50 = 55300.0 nM 4.26
CHEMBL355549 IC50 = 56700.0 nM 4.25
CHEMBL169563 IC50 = 56600.0 nM 4.25
CHEMBL441495 IC50 = 56700.0 nM 4.25
CHEMBL353103 IC50 = 57400.0 nM 4.24
CHEMBL167600 IC50 = 57600.0 nM 4.24
CHEMBL354630 IC50 = 59100.0 nM 4.23
CHEMBL169673 IC50 = 59500.0 nM 4.22
CHEMBL353114 IC50 = 62000.0 nM 4.21
CHEMBL169049 IC50 = 69700.0 nM 4.16