Assay Detail
Functional
CHEMBL655298
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Antiviral activity was determined based on inhibition of HIV-1 IIIB induced cytopathic effects in CEM-SS cells in vitro using tetrazolium reagent.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.72 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53355 | — | — | 1 | 8.22 |
| CHEMBL300891 | — | — | 1 | 8.15 |
| CHEMBL299198 | — | — | 1 | 7.96 |
| CHEMBL54191 | — | — | 1 | 7.72 |
| CHEMBL52279 | — | — | 1 | 7.47 |
| CHEMBL416131 | — | — | 1 | 7.47 |
| CHEMBL300257 | — | — | 1 | 7.04 |
| CHEMBL432887 | — | — | 1 | - |
| CHEMBL54009 | — | — | 1 | - |
| CHEMBL282457 | — | — | 1 | - |
| CHEMBL299514 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53355 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL300891 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL299198 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL54191 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL52279 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL416131 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL300257 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL432887 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL54009 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL282457 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL299514 | — | IC50 | > | 200.0 | nM | - |