Assay Detail
Functional
CHEMBL655299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.83 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7305 | — | — | 1 | 5.62 |
| CHEMBL7652 | — | — | 1 | 5.20 |
| CHEMBL266921 | — | — | 1 | 5.19 |
| CHEMBL269359 | — | — | 1 | 5.19 |
| CHEMBL7485 | — | — | 1 | 5.18 |
| CHEMBL6883 | — | — | 1 | 5.16 |
| CHEMBL7453 | — | — | 1 | 4.96 |
| CHEMBL267208 | — | — | 1 | 4.92 |
| CHEMBL7378 | — | — | 1 | 4.92 |
| CHEMBL267693 | — | — | 1 | 4.85 |
| CHEMBL267679 | — | — | 1 | 4.82 |
| CHEMBL7693 | — | — | 1 | 4.80 |
| CHEMBL7840 | — | — | 1 | 4.75 |
| CHEMBL7633 | — | — | 1 | 4.75 |
| CHEMBL263086 | CALANOLIDE C | — | 1 | 4.75 |
| CHEMBL269090 | — | — | 1 | 4.72 |
| CHEMBL7270 | — | — | 1 | 4.72 |
| CHEMBL7760 | — | — | 1 | 4.70 |
| CHEMBL269063 | — | — | 1 | 4.70 |
| CHEMBL266552 | — | — | 1 | 4.68 |
| CHEMBL266322 | — | — | 1 | 4.68 |
| CHEMBL6968 | — | — | 1 | 4.68 |
| CHEMBL266050 | — | — | 1 | 4.68 |
| CHEMBL269062 | — | — | 1 | 4.66 |
| CHEMBL7211 | — | — | 1 | 4.66 |
| CHEMBL266091 | — | — | 1 | 4.66 |
| CHEMBL267447 | CALANOLIDE A | 1.0 | 2 | 4.64 |
| CHEMBL7242 | — | — | 1 | 4.62 |
| CHEMBL269121 | — | — | 1 | 4.43 |
| CHEMBL267951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7305 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL7652 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL266921 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL269359 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL7485 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL6883 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL7453 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL7378 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL267208 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL267693 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL267679 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL7693 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL7840 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL7633 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL263086 | CALANOLIDE C | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL7270 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL269090 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL7760 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL269063 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL266322 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL266552 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL266050 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL6968 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL7211 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL269062 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL266091 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL267447 | CALANOLIDE A | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL267447 | CALANOLIDE A | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL7242 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL269121 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL267951 | — | IC50 | > | 100000.0 | nM | - |