Assay Detail
Binding
CHEMBL655348
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Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.14 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55788 | — | — | 1 | 5.70 |
| CHEMBL53596 | — | — | 1 | 5.70 |
| CHEMBL52654 | — | — | 1 | 5.52 |
| CHEMBL432130 | — | — | 1 | 5.21 |
| CHEMBL54382 | — | — | 1 | 5.16 |
| CHEMBL301860 | — | — | 1 | 5.12 |
| CHEMBL300138 | ENZASTAURIN | 3.0 | 1 | 5.00 |
| CHEMBL55394 | — | — | 1 | 4.60 |
| CHEMBL291975 | — | — | 1 | 4.23 |
| CHEMBL300549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55788 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL53596 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL52654 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL432130 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL54382 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL301860 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL300138 | ENZASTAURIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL55394 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL291975 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL300549 | — | IC50 | > | 40000.0 | nM | - |