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Compound Detail

CHEMBL301860

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CC(C)N1CCC(n2cc(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c3ccccc32)CC1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL301860
Phase Preclinical
Structure Type MOL
InChI Key KQUBTSBQLPIFSM-UHFFFAOYSA-N
9
Targets
10
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

466.6
MW (Da)
4.75
ALogP
5
HBA
1
HBD
59.3
PSA (Ų)
0.44
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H30N4O2
MW 466.59
Aromatic Rings 4
Heavy Atoms 35
NP-Likeness -0.46

Activity Summary

IC50 10 meas. best 7.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Protein kinase C beta type
CHEMBL3045
 IC50 7.72 7.65 19.0 2
Protein kinase C eta type
CHEMBL3616
 IC50 6.89 6.89 130.0 1
Protein kinase C (PKC)
CHEMBL2094266
 IC50 6.6 6.6 250.0 1
Protein kinase C alpha type
CHEMBL299
 IC50 6.47 6.47 340.0 1
Protein kinase C epsilon type
CHEMBL3582
 IC50 6.41 6.41 390.0 1
Protein kinase C delta type
CHEMBL2996
 IC50 6.01 6.01 970.0 1
Protein kinase C gamma type
CHEMBL2938
 IC50 5.89 5.89 1300.0 1
CaM kinase II
CHEMBL2097164
 IC50 5.12 5.12 7500.0 1
Protein kinase C zeta type
CHEMBL3438
 IC50 5.03 5.03 9300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Protein kinase C beta type IC50 = 19.0 nM 7.72 Inhibition of Protein kinase C beta 1 12749884
Protein kinase C beta type IC50 = 26.0 nM 7.58 Inhibition of Protein kinase C beta 2 12749884
Protein kinase C eta type IC50 = 130.0 nM 6.89 Inhibition of Protein kinase C eta 12749884
Protein kinase C (PKC) IC50 = 250.0 nM 6.6 Inhibition of purified rat brain protein kinase C (RB-PKC) 12749884
Protein kinase C alpha type IC50 = 340.0 nM 6.47 Inhibition of Protein kinase C alpha 12749884
Protein kinase C epsilon type IC50 = 390.0 nM 6.41 Inhibition of Protein kinase C epsilon 12749884
Protein kinase C delta type IC50 = 970.0 nM 6.01 Inhibition of Protein kinase C delta 12749884
Protein kinase C gamma type IC50 = 1300.0 nM 5.89 Inhibition of Protein kinase C gamma 12749884
CaM kinase II IC50 = 7500.0 nM 5.12 Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinase 12749884
Protein kinase C zeta type IC50 = 9300.0 nM 5.03 Inhibition of Protein kinase C zeta 12749884

Literature References

PubMed DOI Target Context # Activities
12749884 10.1016/s0960-894x(03)00286-5 Protein kinase C beta type 2
12749884 10.1016/s0960-894x(03)00286-5 Unchecked 2
12749884 10.1016/s0960-894x(03)00286-5 Protein kinase C alpha type 1
12749884 10.1016/s0960-894x(03)00286-5 Protein kinase C gamma type 1
12749884 10.1016/s0960-894x(03)00286-5 Protein kinase C delta type 1
12749884 10.1016/s0960-894x(03)00286-5 Protein kinase C epsilon type 1
12749884 10.1016/s0960-894x(03)00286-5 Protein kinase C zeta type 1
12749884 10.1016/s0960-894x(03)00286-5 Protein kinase C eta type 1
12749884 10.1016/s0960-894x(03)00286-5 CaM kinase II 1
12749884 10.1016/s0960-894x(03)00286-5 Proto-oncogene tyrosine-protein kinase Src 1
12749884 10.1016/s0960-894x(03)00286-5 Protein kinase C (PKC) 1

Data from ChEMBL 36 via Core Engine