Assay Detail
Binding
CHEMBL767704
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Inhibition of Protein kinase C alpha
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.23 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.35 |
| CHEMBL52654 | — | — | 1 | 6.70 |
| CHEMBL55788 | — | — | 1 | 6.52 |
| CHEMBL55394 | — | — | 1 | 6.52 |
| CHEMBL301860 | — | — | 1 | 6.47 |
| CHEMBL432130 | — | — | 1 | 6.44 |
| CHEMBL54382 | — | — | 1 | 6.40 |
| CHEMBL53596 | — | — | 1 | 6.40 |
| CHEMBL300138 | ENZASTAURIN | 3.0 | 1 | 6.10 |
| CHEMBL291975 | — | — | 1 | 5.42 |
| CHEMBL300549 | — | — | 1 | 5.22 |
| CHEMBL293805 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL52654 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL55788 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL55394 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL301860 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL432130 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL54382 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL53596 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL300138 | ENZASTAURIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL291975 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL300549 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL293805 | — | IC50 | = | 6000.0 | nM | 5.22 |