Assay Detail
Functional
CHEMBL655349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to achieve 50% inhibition of HIV-1 181C (nevirapine-resistant HIV-1) multiplication in CEM-SS cells.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.46 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20610 | — | — | 1 | 6.28 |
| CHEMBL58914 | — | — | 1 | 4.64 |
| CHEMBL57161 | — | — | 1 | - |
| CHEMBL58213 | — | — | 1 | - |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | - |
| CHEMBL440482 | — | — | 1 | - |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20610 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL58914 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL57161 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL58213 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL853 | ZALCITABINE | EC50 | > | 33000.0 | nM | - |
| CHEMBL440482 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | - | nM | - |