Assay Detail
Functional
CHEMBL655359
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Tested for anti-HIV -1 Activity in CEM-SS cell culture
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
S-Acyl-2-thioethyl aryl phosphotriester derivatives as mononucleotide prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.24 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141650 | — | — | 1 | 9.00 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.52 |
| CHEMBL336008 | — | — | 1 | 8.40 |
| CHEMBL291344 | — | — | 1 | 7.82 |
| CHEMBL342461 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141650 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL336008 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL291344 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL342461 | — | EC50 | = | 34.0 | nM | 7.47 |