Assay Detail
Functional
CHEMBL655394
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Inhibitory concentration against mitochondrial DNA synthesis CEM cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.16 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 7.16 |
| CHEMBL306257 | SYNGUANOL | — | 1 | - |
| CHEMBL75950 | — | — | 1 | - |
| CHEMBL75956 | — | — | 1 | - |
| CHEMBL76121 | — | — | 1 | - |
| CHEMBL305612 | — | — | 1 | - |
| CHEMBL74478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL853 | ZALCITABINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL306257 | SYNGUANOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL75950 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL75956 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL76121 | — | IC50 | - | nM | - | |
| CHEMBL305612 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL74478 | — | IC50 | > | 50000.0 | nM | - |