Assay Detail
Functional
CHEMBL655408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against GnRH-stimulated phosphatidyl inositol hydrolysis by cloned chinese hamster ovary cells stably expressing human GnRH receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.12 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48192 | — | — | 1 | 8.66 |
| CHEMBL52278 | — | — | 1 | 8.30 |
| CHEMBL295948 | — | — | 1 | 8.06 |
| CHEMBL48879 | — | — | 1 | 8.01 |
| CHEMBL300295 | — | — | 1 | 7.94 |
| CHEMBL298937 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48192 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL52278 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL295948 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL48879 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL300295 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL298937 | — | IC50 | = | 18.0 | nM | 7.75 |