Assay Detail
Functional
CHEMBL655413
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Drug concentration that inhibit cell growth by 50% compared to un treated control cultures of CHO cells (for 6 days at 37 degree Centigrade)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Intensely potent doxorubicin analogues: structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.71 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405105 | — | — | 1 | 10.00 |
| CHEMBL369851 | — | — | 1 | 9.52 |
| CHEMBL172785 | — | — | 1 | 9.40 |
| CHEMBL173260 | — | — | 1 | 7.58 |
| CHEMBL367998 | — | — | 1 | 7.26 |
| CHEMBL369872 | — | — | 1 | 7.24 |
| CHEMBL354402 | — | — | 1 | 7.19 |
| CHEMBL435344 | — | — | 1 | 7.08 |
| CHEMBL172827 | — | — | 1 | 7.00 |
| CHEMBL172683 | — | — | 1 | 6.92 |
| CHEMBL369873 | — | — | 1 | 6.69 |
| CHEMBL369364 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405105 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL369851 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL172785 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL173260 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL367998 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL369872 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL354402 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL435344 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL172827 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL172683 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL369873 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL369364 | — | IC50 | = | 250.0 | nM | 6.60 |