Assay Detail
Binding
CHEMBL655431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasma
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.77 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151284 | — | — | 1 | 6.40 |
| CHEMBL68399 | — | — | 2 | 5.85 |
| CHEMBL33352 | — | — | 1 | 5.77 |
| CHEMBL356252 | — | — | 1 | 5.19 |
| CHEMBL302067 | — | — | 3 | - |
| CHEMBL150332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151284 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL68399 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL33352 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL68399 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL356252 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL302067 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL150332 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL302067 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL302067 | — | IC50 | > | 50000.0 | nM | - |