Assay Detail
Functional
CHEMBL655544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type HIV-1-IIIB strain replication in CEM-SS cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.96 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357409 | — | — | 1 | 8.52 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.52 |
| CHEMBL343576 | — | — | 1 | 8.00 |
| CHEMBL140532 | — | — | 1 | 8.00 |
| CHEMBL336237 | — | — | 1 | 7.85 |
| CHEMBL128450 | — | — | 1 | 7.30 |
| CHEMBL341880 | — | — | 1 | 7.17 |
| CHEMBL356674 | — | — | 1 | 6.92 |
| CHEMBL343067 | — | — | 1 | 6.60 |
| CHEMBL341931 | — | — | 1 | 6.30 |
| CHEMBL140048 | — | — | 1 | 5.85 |
| CHEMBL142098 | — | — | 1 | 5.55 |
| CHEMBL143635 | — | — | 1 | 5.42 |
| CHEMBL142863 | — | — | 1 | 5.26 |
| CHEMBL131444 | — | — | 1 | 5.18 |
| CHEMBL129076 | — | — | 1 | 5.12 |
| CHEMBL143442 | — | — | 1 | 5.10 |
| CHEMBL143261 | — | — | 1 | 4.84 |
| CHEMBL140898 | — | — | 1 | 4.77 |
| CHEMBL142301 | — | — | 1 | 4.76 |
| CHEMBL342788 | — | — | 1 | 4.75 |
| CHEMBL126931 | — | — | 1 | 4.38 |
| CHEMBL142809 | — | — | 1 | 4.36 |
| CHEMBL142330 | — | — | 1 | 4.35 |
| CHEMBL140041 | — | — | 1 | 4.25 |
| CHEMBL358094 | — | — | 1 | - |
| CHEMBL435674 | — | — | 1 | - |
| CHEMBL143701 | — | — | 1 | - |
| CHEMBL293498 | — | — | 1 | - |
| CHEMBL359240 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357409 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL343576 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL140532 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL336237 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL128450 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL341880 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL356674 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL343067 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL341931 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL140048 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL142098 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL143635 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL142863 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL131444 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL129076 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL143442 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL143261 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL140898 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL142301 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL342788 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL126931 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL142809 | — | IC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL142330 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL140041 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL358094 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL435674 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL143701 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL293498 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL359240 | — | IC50 | ~ | 90.0 | nM | - |
| CHEMBL416107 | — | IC50 | ~ | 6.0 | nM | - |