Assay Detail
Functional
CHEMBL655545
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Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity modifications of the HIV-1 inhibitors (+)-calanolide A and (-)-calanolide B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.16 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344417 | — | — | 1 | 5.28 |
| CHEMBL448418 | — | — | 1 | 5.24 |
| CHEMBL138199 | — | — | 1 | 5.23 |
| CHEMBL7187 | COSTATOLIDE | — | 1 | 5.23 |
| CHEMBL267447 | CALANOLIDE A | 1.0 | 1 | 5.14 |
| CHEMBL337344 | — | — | 1 | 5.10 |
| CHEMBL138469 | 7,8-DIHYDROCALANOLIDE B | — | 1 | 5.09 |
| CHEMBL139026 | — | — | 1 | 5.07 |
| CHEMBL269090 | — | — | 1 | 5.03 |
| CHEMBL345100 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344417 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL448418 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL138199 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL7187 | COSTATOLIDE | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL267447 | CALANOLIDE A | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL337344 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL138469 | 7,8-DIHYDROCALANOLIDE B | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL139026 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL269090 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL345100 | — | IC50 | > | 150000.0 | nM | - |