Assay Detail
Functional
CHEMBL655561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to protect CEM/TK cells against the cytopathicity of HIV-2 by 50%
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Cell Type | CEM/TK |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 7.39 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350117 | — | — | 1 | 8.27 |
| CHEMBL3349838 | — | — | 1 | 8.22 |
| CHEMBL3349832 | — | — | 1 | 7.85 |
| CHEMBL3349834 | — | — | 1 | 7.80 |
| CHEMBL3349831 | — | — | 1 | 7.75 |
| CHEMBL320833 | STAMPIDINE | — | 1 | 7.75 |
| CHEMBL3349836 | — | — | 1 | 7.66 |
| CHEMBL3349845 | — | — | 1 | 7.60 |
| CHEMBL3349842 | — | — | 1 | 7.60 |
| CHEMBL3349837 | — | — | 1 | 7.54 |
| CHEMBL3349843 | — | — | 1 | 7.52 |
| CHEMBL3349839 | — | — | 1 | 7.52 |
| CHEMBL3349835 | — | — | 1 | 7.40 |
| CHEMBL3349844 | — | — | 1 | 7.35 |
| CHEMBL323261 | — | — | 1 | 7.33 |
| CHEMBL3349841 | — | — | 1 | 7.30 |
| CHEMBL3349830 | — | — | 1 | 7.19 |
| CHEMBL3349846 | — | — | 1 | 7.19 |
| CHEMBL107184 | — | — | 1 | 7.12 |
| CHEMBL3349840 | — | — | 1 | 7.05 |
| CHEMBL3349833 | — | — | 1 | 7.05 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350117 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL3349838 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3349832 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3349834 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3349831 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL320833 | STAMPIDINE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3349836 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3349845 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3349842 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3349837 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3349843 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3349839 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3349835 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3349844 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL323261 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3349841 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3349830 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3349846 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL107184 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3349840 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3349833 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL991 | STAVUDINE | EC50 | = | 33000.0 | nM | 4.48 |