Assay Detail
Binding
CHEMBL655571
Review assay metadata, readout intent, target linkage, and publication context from the same page.
IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell line
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.82 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.19 |
| CHEMBL12532 | — | — | 1 | 8.05 |
| CHEMBL280326 | — | — | 1 | 7.92 |
| CHEMBL16819 | — | — | 1 | 7.82 |
| CHEMBL17218 | — | — | 1 | 7.75 |
| CHEMBL279308 | — | — | 1 | 7.75 |
| CHEMBL7162 | NS-398 | — | 1 | 7.66 |
| CHEMBL275188 | — | — | 1 | 7.58 |
| CHEMBL17229 | — | — | 1 | 7.58 |
| CHEMBL16733 | — | — | 1 | 7.16 |
| CHEMBL274990 | SC-58125 | — | 1 | 7.16 |
| CHEMBL417073 | — | — | 1 | 6.96 |
| CHEMBL274457 | — | — | 1 | 6.85 |
| CHEMBL279801 | — | — | 1 | 6.75 |
| CHEMBL16826 | — | — | 1 | 6.68 |
| CHEMBL16843 | — | — | 1 | 6.64 |
| CHEMBL16827 | — | — | 1 | 6.62 |
| CHEMBL16912 | — | — | 1 | 6.58 |
| CHEMBL16828 | — | — | 1 | 6.52 |
| CHEMBL16878 | — | — | 1 | 6.48 |
| CHEMBL16659 | — | — | 1 | 6.46 |
| CHEMBL16814 | — | — | 1 | 6.41 |
| CHEMBL279755 | — | — | 1 | 6.16 |
| CHEMBL276916 | — | — | 1 | 6.04 |
| CHEMBL276062 | — | — | 1 | 5.89 |
| CHEMBL16981 | — | — | 1 | 5.85 |
| CHEMBL278040 | — | — | 1 | 5.82 |
| CHEMBL16891 | — | — | 1 | 5.43 |
| CHEMBL16674 | — | — | 1 | 5.07 |
| CHEMBL273793 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL12532 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL280326 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL16819 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL17218 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL279308 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL7162 | NS-398 | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL275188 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL17229 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL16733 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL274990 | SC-58125 | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL417073 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL274457 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL279801 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL16826 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL16843 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL16827 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL16912 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL16828 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL16878 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL16659 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL16814 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL279755 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL276916 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL276062 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL16981 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL278040 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL16891 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL16674 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL273793 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL17104 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL279336 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16977 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL416165 | — | IC50 | > | 20000.0 | nM | - |