Assay Detail
Functional
CHEMBL655577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to protect CEM/0 cells against the cytopathicity of HIV-1 by 50%
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM/0 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 7.52 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3349838 | — | — | 1 | 8.30 |
| CHEMBL3349834 | — | — | 1 | 8.10 |
| CHEMBL320833 | STAMPIDINE | — | 1 | 8.05 |
| CHEMBL3349831 | — | — | 1 | 8.00 |
| CHEMBL3349837 | — | — | 1 | 7.89 |
| CHEMBL3350117 | — | — | 1 | 7.89 |
| CHEMBL3349843 | — | — | 1 | 7.85 |
| CHEMBL3349832 | — | — | 1 | 7.82 |
| CHEMBL3349839 | — | — | 1 | 7.80 |
| CHEMBL3349830 | — | — | 1 | 7.75 |
| CHEMBL3349846 | — | — | 1 | 7.75 |
| CHEMBL3349842 | — | — | 1 | 7.60 |
| CHEMBL3349835 | — | — | 1 | 7.60 |
| CHEMBL3349845 | — | — | 1 | 7.40 |
| CHEMBL3349836 | — | — | 1 | 7.28 |
| CHEMBL323261 | — | — | 1 | 7.24 |
| CHEMBL107184 | — | — | 1 | 7.12 |
| CHEMBL3349844 | — | — | 1 | 7.10 |
| CHEMBL3349841 | — | — | 1 | 6.96 |
| CHEMBL3349833 | — | — | 1 | 6.89 |
| CHEMBL3349840 | — | — | 1 | 6.82 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3349838 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3349834 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL320833 | STAMPIDINE | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3349831 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3349837 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3350117 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3349843 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3349832 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3349839 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3349830 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3349846 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3349842 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3349835 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3349845 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3349836 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL323261 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL107184 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3349844 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3349841 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3349833 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3349840 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL991 | STAVUDINE | EC50 | = | 651.0 | nM | 6.19 |