Assay Detail
Functional
CHEMBL655585
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Tested for cell-growth inhibition against human leukemic lymphoblast CEM/MTX cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.51 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 6.50 |
| CHEMBL25923 | — | — | 1 | 6.00 |
| CHEMBL28112 | — | — | 1 | 5.66 |
| CHEMBL283062 | — | — | 1 | 5.24 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.18 |
| CHEMBL27306 | — | — | 1 | 5.00 |
| CHEMBL26326 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL25923 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL28112 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL283062 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL27306 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL26326 | — | IC50 | = | 10000.0 | nM | 5.00 |